Of course. This is a very specific and now historical combination. Let's break down the compatibility, the challenges, and the best path forward.

Executive Summary

It is highly recommended that you upgrade your Python version.

Running Python 2.6 is extremely risky today. It is no longer supported, has critical security vulnerabilities, and lacks modern features. While it is technically possible to get a very old version of wxPython working with it, you will face significant limitations and will be unable to use any modern versions of the library or its ecosystem.

Compatibility: wxPython and Python 2.6

The last version of wxPython to officially support Python 2.6 was wxPython 2.8.

• wxPython 2.8 Series: This was the last major branch built for Python 2.x. It is compatible with Python 2.6, 2.7, and also very old versions of Python 3.x (like 3.0 and 3.1).
• wxPython "Phoenix" (wxPython 3.0+): This was a complete rewrite of wxPython and only supports Python 2.7 and Python 3.4+. It dropped support for Python 2.6 entirely.

The Major Problem: wxPython 2.8 is Ancient

While you can install wxPython 2.8 on Python 2.6, you are committing to using a toolkit from the 2008-2010 era. This has several major consequences:

• No Modern Widgets: You will not have access to modern, powerful widgets like wx.dataview.DataViewCtrl (a powerful grid/list control), wx.adv.RichTextCtrl, or many of the enhanced controls available in modern versions.
• Bugs and No Fixes: All known bugs in wxPython 2.8 are permanent. There will be no more updates, bug fixes, or security patches.
• No Unicode Support (Properly): While Python 2.6 had some Unicode support, wxPython 2.8's handling was often clunky and prone to errors, especially with international characters. Modern wxPython has excellent, seamless Unicode support.
• Abandoned Toolkits: Other popular GUI libraries for Python, like PyQt and PySide, also dropped support for Python 2.6 long ago. You would be limited to wxPython if you stick with 2.6.

How to Install (If You Must Insist on Python 2.6)

If you are absolutely required to work with this legacy environment, here is how you would do it. The process is different depending on your operating system.

Prerequisites

You must have the GTK+ development libraries installed on your system. wxPython 2.8 was primarily built against GTK+ 2.

• On Debian/Ubuntu:

  sudo apt-get update
  sudo apt-get install python2.6-dev libgtk2.0-dev libglade2-dev libwebkit-dev libgnomeui-dev

• On Fedora/CentOS/RHEL:

  sudo yum install python26-devel gtk2-devel libglade2-devel webkitgtk-devel libgnomeui-devel

• On Windows: You will need to download and install the GTK+ runtime for Windows from the official GTK+ download page. Make sure to choose the version compatible with wxPython 2.8 (usually GTK+ 2.24).

Installation Steps

1. Download wxPython 2.8: You cannot use pip for this. You need to find the source distribution (.tar.gz or .zip). The most reliable source is the official wxPython 2.8 archive.

   • Download Link: wxPython 2.8.12.1 Source (This is a stable, late-version of the 2.8 series).

2. Unpack and Build: Open a terminal or command prompt, navigate to the directory where you downloaded the file, and unpack it.

   
   （图片来源网络，侵删）

   # For Linux/macOS
   tar -xzf wxPython-src-2.8.12.1.tar.gz
   cd wxPython-src-2.8.12.1
   # For Windows
   # Use a tool like 7-Zip to extract the .zip file
   # Then open the extracted folder in a command prompt
   cd wxPython-src-2.8.12.1

3. Configure and Build: This is the most critical step. You must tell the build system to use your Python 2.6 installation.

   # The ./configure command is for Linux/macOS
   # This is a common configuration, adjust flags as needed
   ./configure --with-python=/usr/bin/python2.6 --with-gtk=2 --enable-debug=no --enable-unicode=yes
   # After configuring, build the library
   make

   • On Windows: The process is different. You typically use the build.py script.

     # In the wxPython-src-2.8.12.1 directory
     python2.6 build.py --gtk2 --unicode

     This will compile the wxWidgets C++ library and then build the Python extension modules.

4. Install: Once the build is complete, install it.

   # For Linux/macOS
   sudo make install
   # For Windows
   # The build.py script usually handles installation, or you might need to run:
   python2.6 setup.py install

5. Install the wxPython Package: Now, navigate into the wxPython subdirectory of the source you extracted and install the Python part.

   cd wxPython
   python2.6 setup.py install

After these steps, you should be able to run python2.6 -c "import wx; print wx.__version__" and see 8.x.

The Strongly Recommended Alternative: Upgrade Your Python

The effort and risk of using Python 2.6 are not worth it. The modern Python ecosystem is vastly superior.

The best path forward is to upgrade to a modern, supported version of Python (3.8+ is recommended).

Benefits of Upgrading:

1. Access to Modern wxPython: You can use the latest wxPython "Phoenix" (version 4.x) or the new wxPython "Oak" (version 4.2+). These versions are actively maintained, fast, have modern widgets, and excellent Unicode support.
2. Security and Stability: You get a secure and stable language with ongoing support.
3. Modern Language Features: You can use print() as a function, f-strings, type hints, and all the other improvements that make Python 3 a joy to use.
4. Access to the Entire Ecosystem: You can use pip to install any modern library, including PyQt6, PySide6, Tkinter, Kivy, etc.

How to Upgrade and Install Modern wxPython:

1. Install Python 3.8+ from python.org.

2. Install wxPython using pip: It's incredibly simple.

   # Open a terminal/command prompt
   # It's good practice to use a virtual environment
   python -m venv my_project_env
   source my_project_env/bin/activate  # On Windows: my_project_env\Scripts\activate
   # Install the latest stable version of wxPython
   pip install -U wxPython

3. Verify the installation:

   python -c "import wx; print(wx.version())"

   This will print a version like 2.1 or higher.

Conclusion

Conclusion: Do not use Python 2.6 for any new development. The time you will spend fighting with an ancient, insecure, and limited toolchain is far better spent upgrading your Python environment and gaining access to a powerful, modern, and supported toolkit.